Celogentin mimetics as inhibitors of tubulin polymerization.

Varsha J Thombare,James A Holden,Eric C Reynolds,Neil M O'Brien-Simpson,Craig A Hutton

JOURNAL OF PEPTIDE SCIENCE（2020）

引用 3|浏览31

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摘要

Bicyclic analogues of celogentin C have been synthesized in which the side chainside chain cross-links are replaced by thioether bonds. Several of the simplified bicyclic peptides displayed potent inhibition of tubulin polymerization.

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