Transcriptomic profile of chicken bone marrow-derive dendritic cells in response to H9N2 avian influenza A virus.

Qingtao Liu,Jing Yang,Xinmei Huang,Yuzhuo Liu,Kaikai Han,Dongmin Zhao,Lijiao Zhang,Yin Li

Veterinary Immunology and Immunopathology（2020）

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摘要

•The first global gene expression analysis of chicken DCs infected with H9N2 AIV.•Up-regulated genes were mainly involved in signal transduction and innate immune/inflammatory responses.•Down-regulated genes were mainly associated with metabolic process and MHC class I antigen processing and presentation.•This study provided a basis for elucidating the immune evasion mechanisms for H9N2 AIV.

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关键词

H9N2 avian influenza A virus,Innate immune response,Antigen presentation,Dendritic cell,RNA-sequencing

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