Next-generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib.
Lung Cancer(2020)
摘要
•Parallel evolution converging on EGFR resistant mutations, C797S/G.•Gain-of-function mutations of CTNNB1 were highly enriched in our cohort.•Concurrent genomic landscape plays an important role in osimertinib resistance.•TP53 inactivating mutations negatively affect patients’ duration of treatment.•The importance of NGS based genetic profiling in the era of precision medicine.
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关键词
EGFR,NSCLC,TKI,NGS,cfDNA,TTD,MAF
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