Effect of drug combinations on the kinetics of antibiotic resistance emergence in Escherichia coli CFT073 using an in vitro hollow-fibre infection model

Narayana Garimella,Tesfalem Zere, Neil Hartman,Adarsh Gandhi, Aschalew Bekele, Xianbin Li, Heather Stone,Leonard Sacks,James L. Weaver

International Journal of Antimicrobial Agents（2020）

引用 6|浏览10

暂无评分

摘要

•Escherichia coli CFT073 develops resistance to ampicillin (AMP), ciprofloxacin (CIP) and fosfomycin (FOF) monotherapies.•AMP, CIP and FOF combinations delayed antibiotic resistance emergence in E. coli.•The HFIM system could potentially be used to identify clinically relevant antibiotic combinations.

查看译文

关键词

In vitro hollow-fibre infection model,Antibiotic resistance,Escherichia coli CFT073,Pharmacokinetics,Antimicrobial agents,Time–kill

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要