Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model.

Shang Piao,Wei Du,Yingliang Wei,Yue Yang,Xinyuan Feng,Lunhao Bai

International Immunopharmacology（2020）

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摘要

•PDX inhibited the IL-1β-induced inflammatory response and ECM degradation in rat chondrocytes.•The anti-inflammatory mechanism of PDX could be the AMPK/NF-κB pathway.•PDX ameliorated osteoarthritis progression in a rat model.•PDX may be a potential therapeutic agent in OA treatment.

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关键词

Osteoarthritis (OA),Protectin DX (PDX),AMP-activated protein kinase (AMPK),Nuclear factor-κB (NF-κB),Chondrocyte

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