RETRACTED ARTICLE: A Porous Ni(II)-MOF for CO 2 Cycloaddition and Protective Effect on Type-II Diabetes via Reducing Cell ROS Production and Cell Apoptosis

The solvothermal reaction of the 5-methoxyisophthalic acid (H 2 mia) ligand and Ni(NO 3 ) 2 ·6H 2 O affords a new highly porous metal–organic framework {[Ni 2 (mia) 2 (H 2 O)](DMF) 4 } n ( 1 ). The structural composing of the as-prepared complex 1 was determined via the elemental analysis and its structural arrangement was probed via the single crystal analysis. Due to its large porous volume along with the abundant open metal sites, complex 1 could be used as a good catalyst for cyclic addition of carbon dioxide to ring oxides under mild conditions of 1 bar carbon dioxide for high yield synthesis of cyclocarbonates. The protective effect of the complex 1 on Type-II diabetes was further evaluated. The inhibitory effect of compound on pancreatic β-cell apoptosis and cell cycle arrest was determined via Annexin V-FITC/PI assay. The oxidative stress state influenced by compound was determined by DCFH-DA assay. The results obtained from molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to Bcl2, which might provide potential regulation mechanisms for the compound.