A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival.

Yvonne de Jong, Fairuz Bennani,Jolieke G van Oosterwijk,Gaia Alberti,Zuzanna Baranski, Pauline Wijers-Koster,Sanne Venneker, Inge H Briaire-de Bruij, Brendy E van de Akker,Hans Baelde,Anne-Marie Cleton-Jansen,Bob van de Water,Erik H J Danen,Judith V M G Bovée

Journal of Bone Oncology（2019）

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摘要

Chondrosarcomas are malignant cartilage tumors that are relatively resistant towards conventional therapeutic approaches. Kinase inhibitors have been investigated and shown successful for several different cancer types. In this study we aimed at identifying kinase inhibitors that inhibit the survival of chondrosarcoma cells and thereby serve as new potential therapeutic strategies to treat chondrosarcoma patients.

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Chondrosarcoma,AURKA,PLK1,CHK1,Screen

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