HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE)

Sajad Karampoor,Hamid Zahednasab,Farah Bokharaei-Salim,Rasoul Mirzaei,Zahra Mojallal-Tabatabaei,Maryam Esghaei,Hossein Keyvani

International Immunopharmacology（2020）

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摘要

•HIV-1 Tat clade B and C attenuated the clinical course of EAE.•HIV-1 Tat clade B and C reduced microgliosis and astrogliosis.•HIV-1 Tat clade B and C incerased the expressions of Bcl-2, but not cleaved caspase-3 and Bax.•HIV-1 Tat clade B and C increased anti-inflammatory cytokines in the serum and spinal cord of EAE mice.•HIV-1 Tat clade B and C decreased the number of T CD4+, but not Tregs.

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关键词

Multiple sclerosis,HIV Tat,Experimental autoimmune encephalomyelitis,Neuroinflammation,Apoptosis

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