Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.

In this report, we demonstrate a "V-shaped" NIRF probe PTO-29, which can monitor A beta oligomers with high selectivity. PTO-29 was designed and showed significant response to A beta oligomers in the fluorescence spectral tests and good properties. In vivo imaging results indicate that 4 month APP/PS1 AD mice have higher signals in the brain than age-matched wild type mice.