Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction.

•Myocardial infarction dramatically increased PAD4 expression and activity in the heart.•PAD4 inhibition can preserve ventricle histological structure and myocardium integrity after myocardial infarction.•PAD4 inhibition protects cardiomyocytes from myocardial infarction induced neutrophil extracellular trap formation and inflammatory cytokine secretion.