The Collagenase Model of Intracerebral Hemorrhage in Awake, Freely Moving Animals: The Effects of Isoflurane.

Cassandra M Wilkinson,Anna C J Kalisvaart,Tiffany F C Kung, D Ryan Maisey,Ana C Klahr,Clayton T Dickson,Frederick Colbourne

Brain Research（2020）

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摘要

•We present a method for inducing ICH in awake animals.•We used telemetry to examine the effect of isoflurane on physiology after ICH.•Physiological confounds induced by isoflurane resolve within minutes to hours.•Post-ICH pain levels were comparable in anesthetized and non-anesthetized models.

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ICH,CBF,BP,EEG,RGS,SWS,RMS,CI

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