PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
Journal of Hepatology(2020)
摘要
•PSMP is highly expressed in fibrotic/cirrhotic livers associated with different liver disease etiologies.•Psmp knockout in mice resulted in a marked amelioration of hepatic fibrosis.•A PSMP-neutralizing antibody significantly alleviates liver fibrosis in mice.•PSMP promotes liver fibrosis through inflammatory macrophages and HSCs via CCR2.•DAMP molecules, HMGB-1 and IL-33, induce mouse hepatocytes to produce PSMP.
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关键词
Chemokine,PSMP,CCR2,Liver fibrosis,Liver cirrhosis,Anti-PSMP antibody,Macrophages,Hepatic stellate cells
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