Pterostilbene supplements carry the risk of drug interaction via inhibition of UDP-glucuronosyltransferases (UGT) 1A9 enzymes.

Lili Jiang,Zhongmin Zhang,Yangliu Xia,Zhen Wang,Xiaoyu Wang,Shujuan Wang,Zhe Wang,Yong Liu

Toxicology Letters（2020）

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摘要

•Potent non-competitive inhibition of pterostilbene against UGT1A9.•Potential risk of drug interaction by pterostilbene supplements via UGT1A9 inhibition.•The mechanism of significant drug interactions associated with pterostilbene supplements.

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关键词

Pterostilbene,Food-drug interactions,UDP- Glucuronosyltransferases,Enzyme inhibition

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