Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Fang Chen
    Fang Chen
    Kenna Nagy
    Kenna Nagy
    Deborah Chavez
    Deborah Chavez
    Shelby Willis
    Shelby Willis
    Andrew Honda
    Andrew Honda

    Gastroenterology, 2019.

    Cited by: 0|Bibtex|Views1|Links
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    Keywords:
    AR3HVR1animal modelmAb

    Abstract:

    In an analysis of vaccinated volunteers, NHPs, and mice, we found that recombinant E1E2 vaccine antigen induces high-antibody titers that are insufficient to neutralize diverse HCV isolates. Antibodies from volunteers and NHPs bind to the same neutralizing epitopes for virus neutralization. NHPs can therefore be used as a preclinical mode...More

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