Monitoring Ceftazidime-Avibactam And Aztreonam Concentrations In The Treatment Of A Bloodstream Infection Caused By A Multidrug-Resistant Enterobacter Sp. Carrying Both Klebsiella Pneumoniae Carbapenemase-4 And New Delhi Metallo-Beta-Lactamase-1

In an infection with an Enterobacter sp. isolate producing Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-beta-Lactamase-1 in the United States, recognition of the molecular basis of carbapenem resistance allowed for successful treatment by combining ceftazidime-avibactam and aztreonam. Antimicrobial synergy testing and therapeutic drug monitoring assessed treatment adequacy.