IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

Paolo Giaccaglia
Paolo Giaccaglia
Erika Casarotta
Erika Casarotta
Vincenzo Gabbanelli
Vincenzo Gabbanelli
Elena Lamura
Elena Lamura
Silvia Ciucani
Silvia Ciucani

Annals of Intensive Care, pp. 1-13, 2019.

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Abstract:

Polyclonal or IgM-enriched immunoglobulins may be beneficial during sepsis as an adjuvant immunomodulatory therapy. We aimed to test whether the infusion of IgM-enriched immunoglobulins improves microvascular perfusion during sepsis. Single-centre, randomized, double-blind, placebo-controlled phase II trial including adult patients with a...More

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