APP-derived peptides reflect neurodegeneration in frontotemporal dementia.

Ignacio Illán-Gala,Jordi Pegueroles,Victor Montal,Daniel Alcolea,Eduard Vilaplana,Alexandre Bejanin,Sergi Borrego-Écija,Frederic Sampedro,Andrea Subirana,María-Belén Sánchez-Saudinós,Ricard Rojas-García,Hugo Vanderstichele,Rafael Blesa,Jordi Clarimón,Anna Antonell,Albert Lladó,Raquel Sánchez-Valle,Juan Fortea,Alberto Lleó

Annals of clinical and translational neurology（2019）

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摘要

APP-derived peptides in CSF may reflect FTLD-related neurodegeneration. This observation has important implications as Aβ1-42 levels are considered an indirect biomarker of cerebral amyloidosis.

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