Risk of Infection Associated With Ibrutinib in Patients With B-Cell Malignancies: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Somedeb Ball,Avash Das,Wasawat Vutthikraivit,Peggy J Edwards,Fred Hardwicke,Nicholas J Short,Gautam Borthakur,Abhishek Maiti

Clinical Lymphoma Myeloma and Leukemia（2020）

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摘要

Our meta-analysis found that ibrutinib was associated with significantly higher risk of infections in patients with B-cell malignancies. Occurrence of major individual subtypes was not different between groups, possibly as a result of inconsistent reporting across studies.

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B-cell lymphoma,Bruton tyrosine kinase,Chronic lymphocytic leukemia,Pneumonia,Relative risk

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