Perturbations in the Activity of Cholinergic Interneurons in the Dorsomedial Striatum Impairs the Update of Actions to an Instrumental Contingency Change.

Neuroscience(2020)

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摘要
•The striatal cholinergic interneurons (CINs) are required to update actions to a contingency change.•Inhibition/perturbation of CINs expressing Arch impairs the update of actions.•Online modulation of CINs on the striatal surrounding cells may be the likely mechanism.
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关键词
DMS,ChAT,Cre,CINs,ROC,CDF,ISI,A1→,A2→,RR
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