Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition.

Yuan Li,Hongguang Chen,Ruichen Shu,Xiaobei Zhang,Yonghao Yu,Xiaofeng Liu,Kuibin Xu

Biochemical and Biophysical Research Communications（2020）

引用 13|浏览3

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摘要

•LPS-induced septic condition leads to decreased expression of junctional proteins resulting in apoptosis of PMVECs.•Under LPS treatment, the application of hydrogen-rich medium can inhibit the activity of RhoA and recover cell viability.•Hydrogen treatment can prevent LPS-induced endothelial barriers destruction through RhoA inhibition.

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关键词

Sepsis,Pulmonary microvascular endothelial cells (PMVECs),Hydrogen-rich medium,Tight junction,Adherens junction,RhoA

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