Don't mess with the machine- evaluation of fluconazole susceptibility testing for Candida glabrata using the new VITEK2 AST-YS08 card following species modification.

A modification of fluconazole formulation in the VITEK2 AST-YS08 card revoked the fluconazole–Candida glabrata combination. An evaluation of AST-YS08 following C. glabrata to C. albicans adjustment within VITEK2 software revealed higher fluconazole MICs compared to AST-YS07 and E-test, with major discrepancies. This mandates an alternative approach to fluconazole–C. glabrata susceptibility testing.