Small cell carcinoma of the bladder: the characteristics of molecular alterations, treatment, and follow-up
Medical Oncology(2019)
摘要
Small cell carcinoma of the bladder (SCCB) is a rare disease associated with high invasiveness and mortality. Histologically, SCCB is difficult to distinguish from small cell lung cancer (SCLC); however, it shares more similar molecular alterations with urothelial carcinoma (UC). As a result, now, the widely accepted theory about the cells of origin is that SCCB and UC probably have a common clone origin. Even the former probably comes from a preexisting UC. At present, given its rarity, early diagnoses, treatments, and follow-ups are not well established, which are vital to patients with SCCB. Inspirationally, in recent years, with the development of molecular diagnostic methods, molecular alterations of SCCB have been understood partially, which are propitious to excavate new potential therapeutic strategies and establish sound follow-ups. Therefore, the future will be light for patients with SCCB.
更多查看译文
关键词
Small cell carcinoma of the bladder, Urothelial carcinoma, Small cell lung cancer, Molecular alterations, Treatment, Follow-up
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络