An injectable chitosan /dextran /β -glycerophosphate hydrogel as cell delivery carrier for therapy of myocardial infarction

Carbohydrate Polymers(2020)

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摘要
•A thermosensitive injectable hydrogels developed as a promising cell delivery vehicle for cardiac cell therapy.•Encapsulation of UCMSCs with CS/1.0 DEX/β-GP hydrogel can improve cell viability.•The delivery of HUVECs from CS/1.0 DEX/β-GP hydrogel showed a linear-like profile.•The prepared hydrogels could modulate the expression level of cTnI and Cx43 receptor of cardiac markers.•A thermosensitive injectable hydrogels developed as a promising cell delivery vehicle for cardiac cell therapy.•Encapsulation of UCMSCs with CS/1.0 DEX/β-GP hydrogel can improve cell viability.•The delivery of HUVECs from CS/1.0 DEX/β-GP hydrogel showed a linear-like profile.•The prepared hydrogels could modulate the expression level of cTnI and Cx43 receptor of cardiac markers.
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关键词
Chitosan,Dextran,β–glycerophosphate,Injectable hydrogel,Cell therapy,Myocardial infarction
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