Preparation and characterization of chemically TEMPO-oxidized and mechanically disintegrated sacchachitin nanofibers (SCNF) for enhanced diabetic wound healing

Fang-Ching Chao,Meng-Huang Wu,Ling-Chun Chen,Hong-Liang Lin,Der-Zen Liu,Hsiu-O Ho,Ming-Thau Sheu

Carbohydrate Polymers（2020）

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摘要

•TEMPO-oxidized SCNF (TOSCNF) and microfludized SCNF (MDSCNF) were prepared and evalued.•All 2% MDSCNF suspension were demonstrated to be in a gel form.•All except T100SC of 2% TOSCNF suspension showed to be wet fiber-like hydrogel.•SCN5/H and T050SC/H accelerated diabetic wound healing to similar as normal tissue.•T050SC/H provided the healed wound as functional tissue instead of scar tissue.

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关键词

2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO),2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (AMPS),Chitosan,PEG1000,PVP K90,L-ascorbic acid, poly(ethylene glycol) diacrylate,N,N-dimethylacrylamide,Sodium hypochlorite,Sodium bromide,Thiazolyl blue tetrazolium bromide (MTT reagent),Irgacure® 184

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