Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions

New oxazolone-based heteromultifunctional linkers were synthesized using a zinc-mediated double functionalization of nitriles as the key step. The orthogonality of the functional groups displayed by this original scaffold was demonstrated by conducting sequential or simultaneous multi-component reactions with amines (oxazolone ring opening), thiols (thiol-ene radical reaction) and azides (Cu-catalyzed azide-alkyne coupling), in respect to the concept of click chemistry.