IN VIVO TRACKING OF TAU PATHOLOGIES WITH 18F-PM-PBB3 (18F-APN-1607) PET IN AD AND DIVERSE NON-AD TAUOPATHIES

existed in a subset of regions across the brain that were not limited to AD-associated regions of the temporal lobe. As such, tau pathology may manifest as a regional pattern of susceptibility motivated, to some degree, by sex-biological mechanisms. Smaller effect sizes, however, support the notion that sex-related risk for tau deposition exists within a milieu of other risk-factors, rather than representing a sole pathway for pathological outcomes. Investigation into the moderating influence of amyloid on sex differences, along with further examination of cohort effects and other noise properties, is needed to understand the dynamics of sex dimorphism on tau deposition.