Psychiatric Disturbance As A Presenting Symptom In Central Nervous Lymphoma

Background: Central nervous system (CNS) lymphoma manifests as a highly aggressive non-Hodgkins lymphoma, either confined to the central nervous system or secondary to spread of systemic diffuse large B cell lymphoma. Rising incidence of CNS lymphoma has been observed, especially in elderly populations. Presentation depends on the burden and location of disease, with a varying spectrum of symptoms ranging from headaches and cognitive changes to focal neurological deficits and seizures. Neuropsychiatric presentation of CNS lymphoma has been seen and anecdotally reported but appears to be under-represented in the literature. In this retrospective review of patients with CNS lymphoma at MCA we report a cohort of patients who presented with primarily neuropsychiatric symptoms