Graft-Vs-Host Reactivity Against The Bone Marrow Is Directed Against The Hematopoietic And Non-Hematopoietic Compartments In Mice

Hematopoietic dysfunction is frequently observed following allogeneic hematopoietic cell transplantation (allo-HCT) and contributes to substantial morbidity. Various factors, e.g. viral infections, poor graft-function, and certain drugs can cause cytopenias, but usually, graft-vs-host disease (GVHD) of the bone marrow (BM) is not taken into account as a major cause of hematopoietic dysfunction, particularly when no other signs of GVHD in classical target organs are present.