Analysis of historical negative control group data from the rat in vivo micronucleus assay

D. P Lovell,M Fellows, J Saul, J Whitwell,L Custer,S Dertinger, P Escobar, R Fiedler, U Hemmann, J Kenny, R Smith, B.M. van der Leede,A Zeller

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2020）

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摘要

•Historical negative control data are important for assessing data quality and for interpretation of the in vivo micronucleus assay•10 laboratories’ data from rat in vivo micronucleus experiments were analyzed statistically.•Mean incidence ranged from 0.44 to 2.22 micronucleated cells/1000 cells

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关键词

In vivo micronucleus assay,Historical negative control data,Quality control statistics,Wistar and Sprague Dawley rats

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