Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy

Leili Rohani,Pranav Machiraju,Rasha Sabouny, Guoliang Meng,Shiying Liu,Tian Zhao,Fatima Iqbal,Amir Ravandi,Joseph C. Wu,Aneal Khan,Timothy Shutt,Derrick Rancourt,Steven C. Greenway

Canadian Journal of Cardiology（2020）

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摘要

We describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.

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