Central Role Of Microrna-21 In Atrial Fibrillation Associated With Structural Remodeling

Eduard Guasch,Sophie Cardin,Xiaobin Luo,Patrice Naud,Khai Le Quang,Yanfen Shi,Jean-C Tardif,Philippe Comtois,Stanley Nattel

Circulation（2012）

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摘要

Background: Heart failure (HF) is a major cause of atrial fibrillation (AF), with fibrosis a putative mechanistic contributor. MiR-21 promotes tissue-fibrosis by downregulating fibroblast Sprouty1,...

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Atrial fibrillation, Heart failure

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