Liraglutide ameliorates palmitate-induced oxidative injury in islet microvascular endothelial cells through GLP-1 receptor/PKA and GTPCH1/eNOS signaling pathways.

Yunyi Le,Rui Wei,Kun Yang,Shan Lang,Liangbiao Gu,Junling Liu,Tianpei Hong,Jin Yang

Peptides（2020）

引用 19|浏览7

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摘要

•PA induces oxidative stress, apoptosis and endothelin-1 secretion dysfunction in MS-1 cells.•Liraglutide ameliorates oxidative injury and endothelin-1 secretion dysfunction induced by PA.•GLP-1R/PKA and GTPCH1/eNOS signaling pathways are involved in the effects of liraglutide.

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关键词

DAHP,DCF,DCFH-DA,eNOS,GLP-1,GLP-1R,GTPCH1,IMECs,L-NAME,PA,PKA,p-PKA,ROS

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