Sox2 + cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence.

Daniel M Treisman,Yinghua Li,Brianna R Pierce,Chaoyang Li, Andrew P Chervenak,Gerald J Tomasek,Guillermina Lozano,Xiaoyan Zheng,Marcel Kool,Yuan Zhu

Neuro-oncology advances（2019）

引用 9|浏览8

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摘要

Quiescent Sox2 cells are efficiently eliminated by p53-mediated apoptosis, but not cell-cycle arrest and differentiation. Their survival contributes to tumor recurrence due to insufficient p53-pathway activation.

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关键词

Sonic Hedgehog medulloblastoma,apoptosis,granule cell precursor,neural precursor,p53

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