Decitabine limits escape from MEK inhibition in uveal melanoma

Jessica Gonçalves Avezedo
Jessica Gonçalves Avezedo
Fernanda Faião-Flores
Fernanda Faião-Flores
Márcia Rosângela Wink
Márcia Rosângela Wink

Pigment cell & melanoma research, 2019.

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Keywords:
DNMTMEKadaptationepigeneticsuveal

Abstract:

MEK inhibitors (MEKi) demonstrate anti-proliferative activity in patients with metastatic uveal melanoma, but responses are short-lived. In the present study, we evaluated the MEKi trametinib alone and in combination with drugs targeting epigenetic regulators, including DOT1L, EZH2, LSD1, DNA methyltransferases and histone acetyltransfera...More

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