Association Between lncRNA and GCKR Gene in Type 2 Diabetes Mellitus.

•Between T2DM and control group, we identified 68 lncRNAs and 74 mRNAs differentially expressed from the expression profile.•Compared with the control group, the expression levels of the GCKR gene and lncRNA ENST00000588707.1 and TCONS_00004187 in the T2DM group were significantly lower.•The correlation analysis revealed that ENST00000588707.1 and TCONS_00004187 were correlated with GCKR gene expression and glycolipid metabolism.•ROC analysis showed that lncRNA ENST0000588707.1 and TCONS_00004187 could serve as potential biomarkers for T2DM.