N16 suppresses RANKL-mediated osteoclatogenesis by down-regulating RANK expression

Jia-Bi Lin,Hao Wu,Yu-Ling Liu,Pang-Chui Shaw,Pei-Bo Li

International Journal of Biological Macromolecules（2020）

引用 2|浏览15

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摘要

•The mechanism of N16 regulating osteoclast differentiation was investigated in vitro.•N16 inhibited the formation of multinucleated osteoclasts and TRAP activity.•N16 inhibited osteoclast differentiation at the early stage of osteoclastogenesis.•N16 inhibited RANK expression by down-regulating the expression of MITF and PU.1.

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关键词

N16,Osteoclatogenesis,RANK,RANKL,Microphthalmia-associated transcription factor,Transcription factor PU.1

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