MicroRNA-223-3p modulates dendritic cell function and ameliorates experimental autoimmune myocarditis by targeting the NLRP3 inflammasome.

Liangqi Chen,Xinyu Hou,Maomao Zhang,Yang Zheng,Xianghui Zheng,Qingyuan Yang, Jing Li,Nan Gu,Min Zhang,Yong Sun,Jian Wu,Bo Yu

Molecular Immunology（2020）

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摘要

•miR-223-3p expression is downregulated in the serum of EAM mice.•miR-223-3p overexpression favors a switch of LPS-stimulated DCs toward a tolerant phenotype.•NLRP3 inflammasome is essential for the tolerogenic function mediated by miR-223-3p.•miR-223-3p-overexpressing DCs ameliorate experimental autoimmune myocarditis in mice.

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关键词

miR-223-3p,EAM,DCs,tDCs,Treg,IL-10,TGF-β,NLRP3,PAMPs,DAMPs,ASC,CARD,mRNAs,IBD,3′-UTR,miRNAs,qRT-PCR,BMDCs,LPS,PBS,siRNA,imDCs,MLR,RIPA,SDS-PAGE,PVDF,TBST,LVEDd,LVEDs,IVSTd,PWTd,H&E,ROC,AUC,siNLRP3,siNC,NC

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