Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARγ.

K A Crawford,B W Clark, W J Heiger-Bernays, S I Karchner,M E Hahn,D E Nacci,J J Schlezinger

Aquatic Toxicology（2020）

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摘要

•TBT induced caudal fin deformity in killifish embryos.•Susceptibility was the same in PCB-sensitive and PCB-tolerant killifish.•An RXR-ligand recapitulated the TBT-induced caudal fin deformity.•Co-treatment with an AHR ligand, PCB126, did not affect the caudal fin deformity.•AHR regulates PPARγ in killifish but PPARγ activity is minimal in embryos.

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关键词

Fundulus heteroclitus,Killifish,Polychlorinated biphenyl,Tributyltin,Aryl hydrocarbon receptor,PPARg,Caudual fin

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