A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application

Yaqi Li
Yaqi Li
Renjie Wang
Renjie Wang
Shaobo Mo
Shaobo Mo
Qiang Guo
Qiang Guo
Guoxiang Fu
Guoxiang Fu
Yuanchuang Li
Yuanchuang Li
Xiaoya Xu
Xiaoya Xu
Xiang Hu
Xiang Hu
Yi Zhou
Yi Zhou
Yun Deng
Yun Deng

Carcinogenesis, 2019.

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Abstract:

Colon signet-ring cell carcinoma (SRCC) is a rare type of malignant dedifferentiated adenocarcinomas, and is associated with poor survival. However, an in-depth study of the biological features of SRCC is hindered by the lack of a reliable in vitro model of colon SRCC. Thus, the establishment of cell cultures from SRCC has become the most...More

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