Patterns of failure and outcomes in cT4 Oral squamous cell carcinoma (OSCC) undergoing upfront surgery in comparison to Neo-Adjuvant Chemotherapy (NACT) followed by surgery: A Matched Pair analysis.

•The role of NACT in T4 oral cancers remains a contentious issue with sparse evidence in literature.•cT4b oral cancers performed better when they received NACT prior to surgery in comparision to cT4a oral cancers.•Results of our matched pair analysis are hypothesis generating which needs to be tested in a randomized trial.