Potential feature exploration and model development based on 18F-FDG PET/CT images for differentiating benign and malignant lung lesions.

•PET parameters and CT-radiomics both have capacity on differentiating lung lesions.•Performance of PET parameters and CT-radiomics do not show significant difference.•The features of SurfaceVolumeRatio and SUVpeak were found as potential biomarker.•SurfaceVolumeRatio differentiates granulomatous lesion from inflammatory pseudotumor.