Verapamil and collagenase differentially affect collagen metabolism in experimental model of Peyronie's disease.

Jacek Karaszewski,Ilona Zareba,Tomasz Guszczyn,Barbara Darewicz,Jerzy Palka

Molecular and Cellular Probes（2020）

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摘要

•Experimental model of Peyronie's disease was established.•Verapamil inhibits collagen biosynthesis by blocking DNA biosynthesis.•Collagenase decreases collagen biosynthesis by inhibiting prolidase activity.•Verapamil and Collagenase attenuate fibrosis phase of Peyronie's disease.

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关键词

Peyronie disease,Collagen biosynthesis,Verapamil,Collagenase

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