Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

Ying Gao, Fangzhong Gui,Demin Li,Ruixue Zhang,Qinyuan Sun,Xiaoying Guo

Environmental Toxicology and Pharmacology（2020）

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摘要

•Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification.•Fluoride activates FGFR3 signaling pathway during endochondral ossification.•Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification.

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关键词

POCs,SOCs,ECM,PG,GAG,HA,CS,HS,KS,DS,HSPG,GPC6,EXT1,FGFs,FGFR3,STAT1,Ihh,PTHrP

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