Lactate up-regulates the expression of PD-L1 in kidney and causes immunosuppression in septic Acute Renal Injury

Jingjing Xu,Xiaohui Ma,Kaili Yu,Ruitao Wang,Sicong Wang,Ruijin Liu,Haitao Liu,Hong Gao,Kaijiang Yu,Changsong Wang

Journal of Microbiology, Immunology and Infection（2021）

引用 22|浏览11

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摘要

Lactate activated PD-1/PD-L1 pathway can induce immunosuppression by inducing apoptosis in lymphocytes in septic AKI. Moreover, blocking the receptor of lactate or PD-1/PD-L1 might be a new therapy for septic AKI.

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关键词

Septic AKI,Lactate,PD-L1,PD-1,T cell,Immunosuppression

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