Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.

Natalie Waldt, David Scharnetzki,Christoph Kesseler,Elmar Kirches, Nele Stroscher,Frank-D Böhmer,Christian Mawrin

Journal of the Neurological Sciences（2020）

引用 8|浏览13

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摘要

•NF2/DEP1 loss increases colony formation in meningioma cells.•NF2/DEP1 loss results in markedly changed cell morphology and cell size.•Cooperative loss of NF2/merlin and DEP1 increases meningioma development rate in mice.

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关键词

Meningioma,Protein tyrosine phosphatase DEP-1/PTPRJ,Neurofibromatosis type 2 (NF2)

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