Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells.

Dipankar Ray,Paramita Ray,Daysha Ferrer-Torres,Zhuwen Wang,Derek Nancarrow,Hee-Won Yoon,May San Martinho,Tonaye Hinton,Scott Owens,Dafydd Thomas,Hui Jiang,Theodore S Lawrence,Jules Lin,Kiran Lagisetty,Andrew C Chang,David G Beer

Gastroenterology（2020）

引用 16|浏览56

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摘要

We found that isoform 2 of RNF128 is decreased in BE cells, resulting in increased levels of mutant p53, whereas isoform 1 of RNF128 is increased in BE cells, further promoting the stabilization of mutant p53.

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关键词

Esophageal Cancer,Post-Transcriptional Regulation,Tumor Suppressor,Alternate Isoform

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