Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells.

Gastroenterology(2020)

引用 16|浏览55
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摘要
We found that isoform 2 of RNF128 is decreased in BE cells, resulting in increased levels of mutant p53, whereas isoform 1 of RNF128 is increased in BE cells, further promoting the stabilization of mutant p53.
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关键词
Esophageal Cancer,Post-Transcriptional Regulation,Tumor Suppressor,Alternate Isoform
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