Genomic heterogeneity in peritoneal implants: A differential analysis of gene expression using nanostring Human Cancer Reference panel identifies a malignant signature.
Gynecologic Oncology(2020)
摘要
•Non-invasive and invasive show distinct differentially expressed genes.•Invasive implants are heterogenous, with a subset genetically similar to high grade serous carcinoma.•Morphology is insufficient to classify peritoneal invasive implants.•Additional studies are required to validate the identified malignant potential prediction.
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关键词
Serous borderline tumor,Invasive implants,Non-invasive implants,HG peritoneal metastasis,Differentially expressed gene,Malignant potential,Nanostring methodology,Precision medicine
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