Immunophenotypic Analysis of CAR-T Cells.

Júlia Teixeira Cottas de Azevedo,Amanda Mizukami,Pablo Diego Moço,Kelen Cristina Ribeiro Malmegrim

Methods in molecular biology (Clifton, N.J.)（2020）

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摘要

CAR-T cell immunotherapy is a promising therapeutic modality for cancer patients. The success of CAR-T cell therapy has been associated with the phenotype, activation and functional profiling of infused CAR-T cells. Therefore, immunophenotypic characterization of CAR-T cells during bioprocess is crucial for cell quality control and ultimately for improved antitumor efficacy. In this chapter, we propose a flow cytometry panel to characterize the immunophenotype of the CAR-T subsets.

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关键词

CAR-T cells,Central memory T cell,Effector T cell,Effector memory T cell,Flow cytometry,Immunophenotypic analysis,Memory stem T cells,Naive T cell,T cells subsets

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