Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.

Baozhen Zeng,Chunlei Ge,Ruilei Li,Zhiwei Zhang,Qiaofen Fu,Zhen Li,Zhuying Lin, Lin Liu,Yuanbo Xue,Yuanyuan Xu,Juan He,Huan Guo,Chunyan Li,Wenhua Huang,Xin Song,Youguang Huang

Biomedicine & Pharmacotherapy（2020）

引用 24|浏览24

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摘要

•MGST1 was highly expressed in LUAD tissues.•MGST1 expression positively correlated with AJCC stage and poor overall survival.•Knocking down MGST1 inhibited LUAD cell proliferation and induced cell apoptosis.•MGST1 knockdown inactivated AKT/GSK-3β pathway signaling in LUAD cells.

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关键词

Microsomal glutathione transferase-1,Lung adenocarcinoma,Proliferation,Apoptosis,AKT/GSK-3β

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