Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function.

Yike Sun,Shanshan Zhou,Hua Guo,Jian Zhang,Tianjiao Ma,Yang Zheng,Zhiguo Zhang,Lu Cai

Metabolism（2020）

引用 84|浏览16

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摘要

•SFN prevention of T2D-induced diabetic cardiomyopathy (DCM) is AMPKα2-dependent.•SFN-stimulated Nrf2-mediated antioxidative effects is AMPKα2-dependent in the heart.•Prevention of DCM by 3-month SFN treatment persists at least 3 more months forward.

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关键词

Sulforaphane,Type 2 diabetes,Cardiomyopathy,Cardiac lipotoxicity,AMPK pathway

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